Heart Failure as a Comorbidity of Diabetes: Role of Dipeptidyl Peptidase 4
نویسندگان
چکیده
منابع مشابه
Play of Chance Versus Concerns Regarding Dipeptidyl Peptidase-4 Inhibitors: Heart Failure and Diabetes.
The delicate balance of disease management versus off-target effects of treatment continues to be a vital concern to both patients and physicians. This article offers a brief overview of heart failure in diabetes and comments on the recent outcome trials of dipeptidyl peptidase-4 (DPP-4) inhibitors, with a closer look at a few pathobiological concerns. The importance of safe antidiabetic treatm...
متن کاملAssociations of dipeptidyl peptidase‐4 inhibitors with mortality in hospitalized heart failure patients with diabetes mellitus
BACKGROUND Heart failure (HF) and diabetes mellitus (DM) often co-exist. Treatment of DM in HF patients is challenging because some therapies for DM are contraindicated in HF. Although previous experimental studies have reported that dipeptidyl peptidase-4 (DPP-4) inhibitors improve cardiovascular function, whether DPP-4 inhibition improves mortality of HF patients with DM remains unclear. Ther...
متن کاملDipeptidyl-peptidase-4 inhibitors for treatment of type 2 diabetes.
OBJECTIVE To assess the efficacy and safety of dipeptidyl peptidase-4 (DPP-4) inhibitors compared with metformin as monotherapy, or with other commonly used hypoglycaemic drugs combined with metformin, in adults with type 2 diabetes mellitus. DESIGN Systematic review and meta-analysis of randomised controlled trials. DATA SOURCES Medline, Embase, the Cochrane Library, conference proceedings...
متن کاملDipeptidyl Peptidase-4 Inhibitor
In the United States, nearly 13% of adults aged 20 years and older have type 2 diabetes mellitus (T2DM), and its prevalence is still increasing (1,2). Microvascular and macrovascular abnormalities are common in patients with T2DM and are related to the severity and duration of hyperglycemia (3–5). Thus, treatment of hyperglycemia is an important way to prevent or delay diabetic vascular complic...
متن کاملDo dipeptidyl peptidase-4 inhibitors increase the risk of heart failure?
SEE PAGE 573 A n association between diabetes and the risk of heart failure has been seen in observational studies. The mechanism is undefined, and it remains unclear whether dipeptidyl peptidase (DPP)-4 this association is related to concomitantmedical problems associated with diabetes (e.g., ischemic heart disease, renal dysfunction, hypertension) or the direct effect of poorly controlled blo...
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ژورنال
عنوان ژورنال: Journal of Atherosclerosis and Thrombosis
سال: 2016
ISSN: 1340-3478,1880-3873
DOI: 10.5551/jat.33225